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Trial Analysis Example of Bayesian MCPMod for Binary Data2 months ago
Scale Conventions in BayesianMCPMod | Calculation of a MAP Prior | 1) Establish MAP prior (beta mixture distribution) | 2) Robustify prior | 3) Translate prior to logit scale (to approximate via normal mixture model) | Specification of reference scale (this follows the idea of [@Neuenschwander2016]). | Specify a prior list | Trial Data | Posterior Calculation | Bayesian MCPMod Test Step | Model Fitting and Visualization | Assessment of the Minimally Efficacious Dose | Additional Note
Trial Simulation Example of Bayesian MCPMod for Binary Data2 months ago
Background and Data | Calculation of a MAP Prior | Specification of the New Trial Design | Calculation of the Success Probabilities
Trial Analysis Example of Bayesian MCPMod for Continuous Data4 months ago
Introduction | Calculation of a MAP Prior | Dose-Response Model Shapes | Trial Data | Posterior Calculation | Bayesian MCPMod Test Step | Model Fitting and Visualization | Assessment of the Minimally Efficacious Dose | Additional Note
Trial Simulation Example of Bayesian MCPMod for Continuous Data4 months ago
Background and Data | Calculation of a MAP Prior | Specification of the New Trial Design | Calculation of the Success Probabilities | Assessment of the Minimally Efficacious Dose
Comparison of Bayesian MCPMod and MCPMod4 months ago
Introduction | Varying the Expected Effect for Maximum Dose | Convergence of Power Values
Introduction to the 'tipmap' package2 years ago
Purpose of the package | Generating data for an exemplary tipping point analysis | Derivation of MAP prior based on trials in the source population | Trial results in the target population | Performing the tipping point analysis | Computation of posteriors for a range of weights | Creating the tipping point plot | Extracting quantities of interest | References
Specifying a primary weight of the informative prior component3 years ago
Introduction | Expert weightings collected using the roulette method | Fitting beta distributions to expert data | Summary statistics | Figures | Without linear pooling | With linear pooling | References
Running bhmbasket on HPC4 years ago
Setup of the parallel backend | Running some bhmbasket code on HPC
Reproducing Parts of Neuenschwander et al. (2016)4 years ago
Analysis of a Basket Trial's Outcome | Creating the trial | Running the model | Getting the estimates | Assessing the Operating Characteristics of a Basket Trial Design | Simulating the scenarios | Running the model | Estimating the biases and MSEs | Estimating the cohort-wise go probabilities | References